[
  {
    "id": "r2-f1",
    "study": "r2",
    "paper_title": "Blockade of the SRC/STAT3/BCL-2 Signaling Axis Sustains the Cytotoxicity in Human Colorectal Cancer Cell Lines Induced by Dehydroxyhispolon Methyl Ether",
    "author": "Hsieh et al.",
    "year": "2023",
    "doi": "10.3390/biomedicines11092530",
    "figure": 1,
    "source": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10526010/#biomedicines-11-02530-f001",
    "retrieval_api": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10526010/supplementaryFiles",
    "retrieved": "2026-10-02",
    "license": "CC BY 4.0",
    "license_url": "https://creativecommons.org/licenses/by/4.0/",
    "modification": "None. Complete original files, CSS display scaling only; Chinese interpretation separately authored.",
    "original_caption": "Figure 1 DHME was more potent and selective than 5-FU to elicit CRC cytotoxicity. Human CRC cell lines HCT-15 and LoVo and normal human colorectal epithelial cell line CCD 841 CoN were subject to 48 h treatment with graded dosage of DHME ( Left ) or 5-FU ( Right ), followed by assessment of cell viability using MTS assay. It appears that 5-FU is cytotoxic to both CRC cell lines and normal colon epithelial cells, whereas DHME kills CRC cells at much lower dosage than 5-FU while also sparing normal colon epithelial cells.",
    "images": [
      {
        "file": "biomedicines-11-02530-g001.jpg",
        "sha256": "648ed71af2ca5e50dc663b65e760900bb81bbd149a9608e8a4b99c71fb6e934d"
      }
    ]
  },
  {
    "id": "r2-f3",
    "study": "r2",
    "paper_title": "Blockade of the SRC/STAT3/BCL-2 Signaling Axis Sustains the Cytotoxicity in Human Colorectal Cancer Cell Lines Induced by Dehydroxyhispolon Methyl Ether",
    "author": "Hsieh et al.",
    "year": "2023",
    "doi": "10.3390/biomedicines11092530",
    "figure": 3,
    "source": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10526010/#biomedicines-11-02530-f003",
    "retrieval_api": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10526010/supplementaryFiles",
    "retrieved": "2026-10-02",
    "license": "CC BY 4.0",
    "license_url": "https://creativecommons.org/licenses/by/4.0/",
    "modification": "None. Complete original files, CSS display scaling only; Chinese interpretation separately authored.",
    "original_caption": "Figure 3 Essential role of STAT3 inhibition in the anti-CRC effect of DHME. ( A , B ) Sustained STAT3 activation blocks DHME-induced apoptosis. Human CRC cell lines stably expressing vector alone or a dominant-active  STAT3  mutant (STAT3 (A661C/N663C); STAT3-C) were treated with DHME (0, 20, 40 μM) for 24 h, followed by immunoblotting for the levels of cleaved PARP (c-PARP) ( A ) or by flow cytometry analysis for the levels of Annexin V-positive population ( B ) to define the extent of DHME-induced apoptosis. ( C ) Sustained STAT3 activation mitigates DHME-induced suppression of CRC colony-forming ability. CRC stable clones of vector control or STAT3-C were subject to clonogenicity assay to measure their cell viability following DHME treatment. GAPDH levels were used as equal loading control. **  p  < 0.002; ***  p  < 0.001.",
    "images": [
      {
        "file": "biomedicines-11-02530-g003a.jpg",
        "sha256": "195570a619294b8ba08ba3489998eb5e5501d3c6c2817e6fa9f5e5e0941fefed"
      },
      {
        "file": "biomedicines-11-02530-g003b.jpg",
        "sha256": "58e1b93946e2a011f50795ba4b89c3639fb042e2d664b51a4d3ab096e3fa8d29"
      }
    ]
  },
  {
    "id": "r10-f6",
    "study": "r10",
    "paper_title": "The Liquid-Fermentation Formulation of Sanghuangporus sanghuang Optimized by Response Surface Methodology and Evaluation of Biological Activity of Extracellular Polysaccharides",
    "author": "Gao et al.",
    "year": "2024",
    "doi": "10.3390/foods13081190",
    "figure": 6,
    "source": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11049023/#foods-13-01190-f006",
    "retrieval_api": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11049023/supplementaryFiles",
    "retrieved": "2026-10-02",
    "license": "CC BY 4.0",
    "license_url": "https://creativecommons.org/licenses/by/4.0/",
    "modification": "None. Complete original files, CSS display scaling only; Chinese interpretation separately authored.",
    "original_caption": "Figure 6 Response surface stereograms based on the Box–Behnken design for the optimization of liquid-fermentation-media components for growing  S. sanghuang . (( A1 – A3 )–( C1 – C3 )) Corresponding contour values. ( D1 – D3 ) Interactions between different concentrations of carbon and nitrogen sources. ( E1 – E3 ) Interactions between different concentrations of the carbon source and the dandelion powder. ( F1 – F3 ) Interactions between different concentrations of the nitrogen source and the dandelion powder.",
    "images": [
      {
        "file": "foods-13-01190-g006.jpg",
        "sha256": "554add58d50b0949a8c80a25eeff8689ebd6105204f83e8fc61abbcea5f25487"
      }
    ]
  },
  {
    "id": "r10-f7",
    "study": "r10",
    "paper_title": "The Liquid-Fermentation Formulation of Sanghuangporus sanghuang Optimized by Response Surface Methodology and Evaluation of Biological Activity of Extracellular Polysaccharides",
    "author": "Gao et al.",
    "year": "2024",
    "doi": "10.3390/foods13081190",
    "figure": 7,
    "source": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11049023/#foods-13-01190-f007",
    "retrieval_api": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11049023/supplementaryFiles",
    "retrieved": "2026-10-02",
    "license": "CC BY 4.0",
    "license_url": "https://creativecommons.org/licenses/by/4.0/",
    "modification": "None. Complete original files, CSS display scaling only; Chinese interpretation separately authored.",
    "original_caption": "Figure 7 Validation of the optimized liquid fermentation formulation for growing  S. sanghuang . ( A ) The CK group (PDB) and optimized-fermentation-liquid-growth formulations for  S. sanghuang . ( B ) The mycelial biomass for the MS-1, MS-3, and MS-7 strains of  S. sanghuang  with the control and optimized formulations. Note: ** represents  p  < 0.01 compared with the CK (PDB) group.",
    "images": [
      {
        "file": "foods-13-01190-g007.jpg",
        "sha256": "34b2c436647ce1859d1232ccc5ffef6dcfa3e6261dc38e542a58b9b08b750d3a"
      }
    ]
  },
  {
    "id": "r10-f9",
    "study": "r10",
    "paper_title": "The Liquid-Fermentation Formulation of Sanghuangporus sanghuang Optimized by Response Surface Methodology and Evaluation of Biological Activity of Extracellular Polysaccharides",
    "author": "Gao et al.",
    "year": "2024",
    "doi": "10.3390/foods13081190",
    "figure": 9,
    "source": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11049023/#foods-13-01190-f009",
    "retrieval_api": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11049023/supplementaryFiles",
    "retrieved": "2026-10-02",
    "license": "CC BY 4.0",
    "license_url": "https://creativecommons.org/licenses/by/4.0/",
    "modification": "None. Complete original files, CSS display scaling only; Chinese interpretation separately authored.",
    "original_caption": "Figure 9 MTT assay results show the effects of the polysaccharides extracted from  S. sanghuang  on the growth of various cancer cells.",
    "images": [
      {
        "file": "foods-13-01190-g009.jpg",
        "sha256": "176a4a75242eae1e6b5d3837bb21b26d718d3436ad4a367d4ef80a251a10c884"
      }
    ]
  },
  {
    "id": "r13-f2",
    "study": "r13",
    "paper_title": "Multi-Target Protective Effects of Sanghuangporus sanghuang Against 5-Fluorouracil-Induced Intestinal Injury Through Suppression of Inflammation, Oxidative Stress, Epitheli-Al-Mesenchymal Transition, and Tight Junction",
    "author": "Lin et al.",
    "year": "2025",
    "doi": "10.3390/ijms26073444",
    "figure": 2,
    "source": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11989720/#ijms-26-03444-f002",
    "retrieval_api": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11989720/supplementaryFiles",
    "retrieved": "2026-10-02",
    "license": "CC BY 4.0",
    "license_url": "https://creativecommons.org/licenses/by/4.0/",
    "modification": "None. Complete original files, CSS display scaling only; Chinese interpretation separately authored.",
    "original_caption": "Figure 2 The effect of SS on H&E staining ( A ) and Ki-67 ( B ) expression was analyzed in the intestinal tissues of 5-FU-treated mice. Histopathological observations were made using H&E and Ki-67-stained sections under a light microscope. SS at 250 and 500 mg/kg was given daily for 10 days, while 5-FU was administered between days 4 and 7. Mice were sacrificed on the 10th day. Data are expressed as mean ± SD ( n  = 5). ###  p  < 0.001 compared to control group; ##  p  < 0.01 compared to control group. ***  p  < 0.001 compared to 5-FU group. Magnification, ×100; scale bar, 100 µm.",
    "images": [
      {
        "file": "ijms-26-03444-g002a.jpg",
        "sha256": "046906b2ec2ac3bf5e48bc5603e3486685fedb2d84e0924ab93d5420305230e1"
      },
      {
        "file": "ijms-26-03444-g002b.jpg",
        "sha256": "8171c08cc68ee244d545a1aea81e55022bf552f772a77216156e4f9d3d0d7542"
      }
    ]
  }
]